abstract：:The abnormal expression of long noncoding RNAs (lncRNAs) is associated with human carcinoma. The present study aimed to investigate the mechanisms underlying the function of lncRNA AK002107 in the progression of hepatocellular carcinoma (HCC). The differential expression of lncRNAs between HCC and paired nontumor tiss...

journal_title：Molecular oncology

authors： Tang YH,He GL,Huang SZ,Zhong KB,Liao H,Cai L,Gao Y,Peng ZW,Fu SJ

更新日期：2019-05-01 00:00:00

abstract：:The main components of the cancer research continuum are basic/preclinical research, early and late clinical research and, after the adoption of an innovation by the healthcare or health organisations, outcomes research. Translational cancer research, defined as a coherent cancer research continuum, is mandatory to ad...

journal_title：Molecular oncology

authors： Ringborg U

更新日期：2019-03-01 00:00:00

abstract：:Cancer is a massive challenge with a significant impact on society, healthcare systems, the economy and an increasing number of patients and their families. To help meet this societal challenge, the European Commission has recently proposed a mission-oriented approach to cancer in Horizon Europe, and about 60 particip...

journal_title：Molecular oncology

authors： European Academy of Cancer Sciences.

更新日期：2019-03-01 00:00:00

abstract：:In order to secure high-quality cancer care for increasing numbers of cancer patients in the upcoming decades, the complete continuum of cancer research and cancer care needs a thorough overhaul, with more emphasis on prevention and early detection, and a greater focus on the development of innovative treatments that ...

journal_title：Molecular oncology

authors： Berns A

更新日期：2019-03-01 00:00:00

abstract：:Ovarian cancer is the most lethal gynecologic malignancy. About 75% of ovarian cancer patients relapse and/or develop chemo-resistant disease after initial response to standard-of-care treatment with platinum-based therapies. HER2 amplifications and overexpression in ovarian cancer are reported to vary, and responses ...

journal_title：Molecular oncology

authors： Harris FR,Zhang P,Yang L,Hou X,Leventakos K,Weroha SJ,Vasmatzis G,Kovtun IV

更新日期：2019-02-01 00:00:00

abstract：:The identification of novel antimetastatic therapeutic targets is necessary for improved treatment of patients with acquired BRAF inhibitor-resistant (BRAFi-R) melanoma, in whom metastasis is a major concern. Our present study focused on the identification of such targets to explore novel antimetastatic therapeutic op...

journal_title：Molecular oncology

authors： Mohapatra P,Prasad CP,Andersson T

更新日期：2019-02-01 00:00:00

abstract：:Central nervous system (CNS) metastasis is one of the serious complications of epidermal growth factor receptor (EGFR)-mutant lung cancer, which arises due to poor penetration of the brain-blood barrier by EGFR-tyrosine kinase inhibitors (EGFR-TKIs). Although osimertinib, a third-generation EGFR-TKI, has efficacy agai...

journal_title：Molecular oncology

authors： Kim DH,Choi YJ,Sung KJ,Yoo SA,Sung YH,Kim JK,Choi CM,Yun M,Lee EY,Jin YS,Cook S,Rho JK,Lee JC

更新日期：2018-12-01 00:00:00

abstract：:Protein inhibitor of activated STAT3 (PIAS3) is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. We previous...

journal_title：Molecular oncology

authors： He T,McColl K,Sakre N,Chen Y,Wildey G,Dowlati A

更新日期：2018-12-01 00:00:00

abstract：:Estrogen receptor-alpha (ERα)-positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ERα activity requires the functional involvement of pioneer factors FOXA1 and GATA3, which enable ERα-chromatin binding and are crucial for ERα-dr...

journal_title：Molecular oncology

authors： Schrijver W,Schuurman K,van Rossum A,Droog M,Jeronimo C,Salta S,Henrique R,Wesseling J,Moelans C,Linn SC,van den Heuvel M,van Diest P,Zwart W

更新日期：2018-11-01 00:00:00

abstract：:Targeted therapy for patients with HER2-positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor (ER) and HER2 expression has been proposed to play a key role in treatment failure, but little work...

journal_title：Molecular oncology

authors： Rye IH,Trinh A,Saetersdal AB,Nebdal D,Lingjaerde OC,Almendro V,Polyak K,Børresen-Dale AL,Helland Å,Markowetz F,Russnes HG

更新日期：2018-11-01 00:00:00

abstract：:Endoplasmic reticulum (ER) stress is an adaptive response to various stress conditions and plays emerging roles in cancer. Activating transcription factor 6 (ATF6), one of the three major ER stress transducers, has been shown to contribute to chemoresistance by altering cancer cell survival. Cancerous inhibitor of pro...

journal_title：Molecular oncology

authors： Liu CY,Hsu CC,Huang TT,Lee CH,Chen JL,Yang SH,Jiang JK,Chen WS,Lee KD,Teng HW

更新日期：2018-10-01 00:00:00

abstract：:Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids (FAs) in BrCa biology remains to be determined. We recently reported that adipocyte coculture alte...

journal_title：Molecular oncology

authors： Balaban S,Lee LS,Varney B,Aishah A,Gao Q,Shearer RF,Saunders DN,Grewal T,Hoy AJ

更新日期：2018-09-01 00:00:00

abstract：:We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PG...

journal_title：Molecular oncology

authors： Gong J,Lang BJ,Weng D,Eguchi T,Murshid A,Borges TJ,Doshi S,Song B,Stevenson MA,Calderwood SK

更新日期：2018-08-01 00:00:00

abstract：:The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to classical microtubule-targeting agents. Using docetaxel and vinorelbi...

journal_title：Molecular oncology

authors： Gerhards NM,Blomen VA,Mutlu M,Nieuwenhuis J,Howald D,Guyader C,Jonkers J,Brummelkamp TR,Rottenberg S

更新日期：2018-06-01 00:00:00

abstract：:Next-generation sequencing (NGS) has recently been rapidly adopted in the molecular diagnosis of cancer, but it still faces some obstacles. In this study, 665 lung adenocarcinoma samples (558 TKI-naive and 107 TKI-relapsed samples) were interrogated using NGS, and the challenges and possible solutions of subjecting ap...

journal_title：Molecular oncology

authors： Li W,Qiu T,Ling Y,Gao S,Ying J

更新日期：2018-05-01 00:00:00

abstract：:Breast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their...

journal_title：Molecular oncology

authors： Carrascal MA,Silva M,Ramalho JS,Pen C,Martins M,Pascoal C,Amaral C,Serrano I,Oliveira MJ,Sackstein R,Videira PA

更新日期：2018-05-01 00:00:00

abstract：:Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it remains undetermined whether and how cigarette smoke affects the therapeutic efficacy of...

journal_title：Molecular oncology

authors： Tu CY,Cheng FJ,Chen CM,Wang SL,Hsiao YC,Chen CH,Hsia TC,He YH,Wang BW,Hsieh IS,Yeh YL,Tang CH,Chen YJ,Huang WC

更新日期：2018-05-01 00:00:00

abstract：:The interferon-inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex-specific STAT1 functions in colitis and colitis-associated colorectal cancer (CRC) using mice with specific STAT1 deletion in intestinal epithelial cells (STAT1∆IEC ). Male but not female STAT1∆IEC mi...

journal_title：Molecular oncology

authors： Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R

更新日期：2018-04-01 00:00:00

abstract：:Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11 E3 ligase, which specifically ubiquitinates and degrades the cyclin-dependent kinase (C...

journal_title：Molecular oncology

authors： Zhang C,Chen B,Jiang K,Lao L,Shen H,Chen Z

更新日期：2018-04-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC), the most refractory subtype of breast cancer to current treatments, accounts disproportionately for the majority of breast cancer-related deaths. This is largely due to cancer plasticity and the development of cancer stem cells (CSCs). Recently, distinct yet interconvertible mesen...

journal_title：Molecular oncology

authors： Sulaiman A,McGarry S,Li L,Jia D,Ooi S,Addison C,Dimitroulakos J,Arnaout A,Nessim C,Yao Z,Ji G,Song H,Gadde S,Li X,Wang L

更新日期：2018-04-01 00:00:00

abstract：:Deregulation of the insulin-like growth factor (IGF) axis and dysbalance of components of the IGF system as potential therapeutic targets have been described in different tumor types. IGF2 is a major embryonic growth factor and an important activator of IGF signaling. It is regulated by imprinting in a development- an...

journal_title：Molecular oncology

authors： Küffer S,Gutting T,Belharazem D,Sauer C,Michel MS,Marx A,Trojan L,Ströbel P

更新日期：2018-02-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer-related pathways. Because APE1 is essential for cell viability, generation of APE1-knockout cell lines and determining a comprehensive list of genes...

journal_title：Molecular oncology

authors： Shah F,Goossens E,Atallah NM,Grimard M,Kelley MR,Fishel ML

更新日期：2017-12-01 00:00:00

abstract：:Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell-to-cell communication within the tumor microenvironment. EVs' components, such as proteins, noncoding RNAs [microRNAs (miRNAs...

journal_title：Molecular oncology

authors： Bayraktar R,Van Roosbroeck K,Calin GA

更新日期：2017-12-01 00:00:00

abstract：:High throughput gene expression profiling has showed great promise in providing insight into molecular mechanisms. Metastasis-related mRNAs may potentially enrich genes with the ability to predict cancer recurrence, therefore we attempted to build a recurrence-associated gene signature to improve prognostic prediction...

journal_title：Molecular oncology

authors： Tian X,Zhu X,Yan T,Yu C,Shen C,Hu Y,Hong J,Chen H,Fang JY

更新日期：2017-11-01 00:00:00

abstract：:Genetic alterations responsible for the initiation of cancer may serve as immediate biomarkers for early diagnosis. Plasma levels of cell-free DNA (cfDNA) in patients with cancer are higher than those in healthy individuals; however, the major technical challenge for the widespread implementation of cfDNA genotyping a...

journal_title：Molecular oncology

authors： Ono Y,Sugitani A,Karasaki H,Ogata M,Nozaki R,Sasajima J,Yokochi T,Asahara S,Koizumi K,Ando K,Hironaka K,Daito T,Mizukami Y

更新日期：2017-10-01 00:00:00

abstract：:Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS-ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain-containing endochondral bone protein chondromodulin I (CHM1) in ES pathogenes...

journal_title：Molecular oncology

authors： von Heyking K,Calzada-Wack J,Göllner S,Neff F,Schmidt O,Hensel T,Schirmer D,Fasan A,Esposito I,Müller-Tidow C,Sorensen PH,Burdach S,Richter GHS

更新日期：2017-09-01 00:00:00

abstract：:Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK+ ) T-cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM-ALK+ T-cell lymphoma is not completely understood. Wild-type ALK is a receptor tyrosine kinase that is physiologically expressed in ...

journal_title：Molecular oncology

authors： Shi W,George SK,George B,Curry CV,Murzabdillaeva A,Alkan S,Amin HM

更新日期：2017-09-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combina...

journal_title：Molecular oncology

authors： Vitale G,Dicitore A,Pepe D,Gentilini D,Grassi ES,Borghi MO,Gelmini G,Cantone MC,Gaudenzi G,Misso G,Di Blasio AM,Hofland LJ,Caraglia M,Persani L

更新日期：2017-08-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma interaction in PD...

journal_title：Molecular oncology

authors： Veenstra VL,Damhofer H,Waasdorp C,Steins A,Kocher HM,Medema JP,van Laarhoven HW,Bijlsma MF

更新日期：2017-08-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important process in embryonic development, fibrosis, and cancer metastasis. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive, and stem-like properties. A growing body of evidence supports the critical link between EMT an...

journal_title：Molecular oncology

authors： Liao TT,Yang MH

更新日期：2017-07-01 00:00:00

abstract：:Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters progression to a metastatic stage, as has been extensively reviewed lately. Indeed, inflammatory cells persisting in the tu...

journal_title：Molecular oncology

authors： Suarez-Carmona M,Lesage J,Cataldo D,Gilles C

更新日期：2017-07-01 00:00:00

abstract：:Gain-of-function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor-initiating cell functions. We determined that in cells expres...

journal_title：Molecular oncology

authors： Vaughan CA,Singh S,Grossman SR,Windle B,Deb SP,Deb S

更新日期：2017-06-01 00:00:00

abstract：:The small heat-shock protein of 27 kDa (HSP27) is highly expressed in many cancers and is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance to chemotherapy. We aimed at assessing the role of HSP27 in modulating responses to target therapies. We selected several oncogene-addicted ca...

journal_title：Molecular oncology

authors： Konda JD,Olivero M,Musiani D,Lamba S,Di Renzo MF

更新日期：2017-06-01 00:00:00

abstract：:Although mutations in the phosphoinositide 3-kinase catalytic subunit (PIK3CA) are common in breast cancer, PI3K inhibitors alone have shown modest efficacy. We sought to identify additional pathways altered in PIK3CA-mutant tumors that might be targeted in combination with PI3K inhibitors. We generated two transgenic...

journal_title：Molecular oncology

authors： Merino VF,Cho S,Liang X,Park S,Jin K,Chen Q,Pan D,Zahnow CA,Rein AR,Sukumar S

更新日期：2017-05-01 00:00:00

abstract：:Extravasation and metastatic progression are two main reasons for the high mortality rate associated with cancer. The metastatic potential of cancer cells depends on a plethora of metabolic challenges prevailing within the tumor microenvironment. To achieve higher rates of proliferation, cancer cells reprogram their m...

journal_title：Molecular oncology

authors： Ray U,Roy Chowdhury S,Vasudevan M,Bankar K,Roychoudhury S,Roy SS

更新日期：2017-05-01 00:00:00

abstract：:It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cr...

journal_title：Molecular oncology

authors： Halvorsen AR,Helland Å,Gromov P,Wielenga VT,Talman MM,Brunner N,Sandhu V,Børresen-Dale AL,Gromova I,Haakensen VD

更新日期：2017-02-01 00:00:00

abstract：:Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone targets. These important post-translational modifications are exquisitely regulated and affect chromatin compaction and transcriptional programs leading to diverse biological outcomes. There is a...

journal_title：Molecular oncology

authors： Michalak EM,Visvader JE

更新日期：2016-12-01 00:00:00

abstract：:Deregulation of microRNAs contributes to the aberrant growth of hepatocellular carcinoma (HCC). Here, we showed that miR-634 expression was frequently decreased in HCC. Low miR-634 expression was significantly associated with larger tumor size, poorer tumor differentiation, advanced TNM stage, vascular invasion, absen...

journal_title：Molecular oncology

authors： Zhang CZ,Cao Y,Fu J,Yun JP,Zhang MF

更新日期：2016-12-01 00:00:00

abstract：:Near infrared photoimmunotherapy (NIR-PIT) is a new, highly-selective cancer theranostics that employs an antibody-photo absorber conjugate (APC). NIR-PIT has successfully treated preclinical tumor models with APCs and is now in the first-in-human phase 1 clinical trial for head and neck cancer patients against EGFR. ...

journal_title：Molecular oncology

authors： Nagaya T,Nakamura Y,Sato K,Harada T,Choyke PL,Kobayashi H

更新日期：2016-11-01 00:00:00

abstract：:Modern technologies enable detection and characterization of circulating tumor cells (CTC) in peripheral blood samples. Thus, CTC have attracted interest as markers for therapeutic response in breast cancer. First studies have incorporated CTC analyses to guide therapeutic interventions and stratification of breast ca...

journal_title：Molecular oncology

authors： Gasch C,Oldopp T,Mauermann O,Gorges TM,Andreas A,Coith C,Müller V,Fehm T,Janni W,Pantel K,Riethdorf S

更新日期：2016-10-01 00:00:00